ASSIGNMENT:

 Create a poster that visually details the ROUTE OF ADMINISTRATION of a specific drug as it is ABSORBED, METABOLIZED and EXCRETED by the human body.

 In the presentation discuss the progress of the drug from administration to excretion in a step-by-step way.

 In other words, chart the progress of a specific drug from its point of entry into the body as it moves through the various organs, tissues, and structures of the body until the drug, or its metabolites are excreted. For example, if your assignment was on the intravenous use of heroin, the poster should include a drawing, diagram, or photograph of a syringe; of heroin itself; of a needle puncturing a vein; of heroin travelling through the circulatory system to the various organs, and so on.

In both the poster and the presentation, be sure to specify:

• the route of administration (a.k.a. how the drug got in the body)
• the drug itself.
• how the drug gets from the point of entry into the circulatory system (if applicable)
• what happens next (Where does it go? How does it get there?)
• the organs and tissues involved in breaking the drug down
• how/where the body excrete the drug or it’s metabolites.

Patrick is a 70-year-old male with a history of stomach complaints and recent tests showing liver enzyme abnormalities. When Patrick visited the clinic this morning, she weighed in at 145 pounds. He presented with upper respiratory symptoms attributable to allergy and was prescribed a decongestant and an antihistamine.

1. List all factors from the patient's story (1 mark).
2. From all the factors you listed from question 1, identify those that you feel are relevant. (1 mark)
3. Pick two of the factors you identified in question 2 and for each one, write down what part of administration, absorption, distribution, metabolism and/or excretion they affect. (1 mark)
4. For each factor you selected in question 3, pick one of the parts you identified as being affected and explain, in detail and in your own words, how and why it would have that affect. (3 marks)
5. Based on what you answered in question 4, what change(s) would you suggest to the medication they were prescribed and why? (1 mark)

Exploring the potential impacts of individual factors on ADME

Scenario:

Joanne is a 35-year-old female with a medical history of stomach complaints but no evidence of ulcer. When Joanne visited the clinic this morning, she weighed in at 324 pounds. ¡ She presented with upper respiratory symptoms attributable to allergy and was prescribed a decongestant and an antihistamine.

1. Read the scenario a couple of times, making sure to pay attention to the details.
2. Write down factors about the individual that you can identify from the scenario.
   § Think about the factors discussed on slides 4 and 5
3. Look at the factors that you listed in Step 2 and write out the ones that you
   believe should be considered when determining the drug dose that should be
   given.
   § Are there any factors that you believe would require the drug dose to be
   increased or decreased?
4. For each factor you identified in Step 3, write down what part of ADME they could
   affect.
   § In some instances, it could be more than one.
   § You can also consider administration here.
5. Pick one of the factors you identified in Step 4 and one of the parts of ADME (if
   there is more than one) and explain in detail how that factor affects that part of
   ADME.
6. Make a recommendation, based on the explanation that you provided in Step 5,
   for how the drug dose or other feature should be changed.
7. Repeat steps 5 and 6 for each of the other factors you identified, each time
   focusing on a different part of ADME (or another feature).

Can you please help with this assignment? This is all the professor has given to us and I am stuck.

Acid-Base Imbalances

Diabetic ketoacidosis

Prolonged vomiting

Barbiturate poisoning

Emphysema

Antacid overdose

Hyperventilation

Thoracic or abdominal surgery

Kidney failure

H+ high

H+ low

pH high

pH low

Respiratory acidosis

Respiratory

alkalosis

Metabolic acidosis

Metabolic alkalosis

Respiratory compensation by hyperventilation

Respiratory compensation by hypoventilation

Renal compensation by H+ excretion

Renal compensation by H+ reabsorption

Instructions for completing the Acid/Base Imbalance Worksheet

1. In each vertical column, there is a list of illnesses or conditions.
2. It the horizontal column are a list of descriptions.
3. Place an “X” in the box that best describes each illness or condition.
4. For example, look at the Diabetic Ketoacidosis column.
   1. Place an X in the first box if the H+ is high.
   2. Place an X in the second box if the H+ is low.
   3. Place an X in the third box if the pH would be high.
   4. Place an X in the fourth box if the pH would be low.
   5. Place an X in the fifth box if diabetic ketosis is a respiratory acidosis condition.
   6. Place an X in the sixth box if diabetic ketoacidosis is a respiratory alkalosis condition.
   7. Place an X in the seventh box if this condition is a metabolic acidosis condition.
   8. Place an X in the eighth box if this condition is a metabolic alkalosis condition.
   9. Continue down the column until you have marked an X in each box that applies to diabetic ketoacidosis.
5. Each vertical column will have exactly 4 X’s.