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16 Jan 2022

Background and context

Erythropoietin, interleukins, growth hormone, as well as interferon receptors, are all members of the cytokine receptor family, which includes this receptor. The receptor's cytosolic JAK kinases are activated by ligand interaction, and this sets off intracellular signalling cascades.
 
Cell-surface receptors, such as those for insulin as well as numerous growth factors, belong to the RTK family, which includes receptor tyrosine kinase. This protein kinase activity is activated in the cytosolic domain of the receptor upon engagement of a ligand, resulting in the initiation of intracellular signalling processes.

 

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