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The thermodynamic data shown in the table below provide insight into the n physicochemical basis of what are sometimes loosely referred to as "hydrophobic interactions". As you can see, the Gibbs free energy changes, where Delta G = Delta H -T Delta S, for the transfer of a hydrocarbon from an aqueous solution to a nonpolar solvent is negative in all cases, which is what you would expect. However, what is perhaps surprising is that these transfer processes are endothermic for aliphatic compounds and athermic (Delta H = 0) for aromatic compounds. That is, it is enthalpically more or equally favorable for nonpolar molecules to dissolve in water than in nonpolar media. In contrast, the entropic component of the free energy change, -T Delta S, is large and negative. What does this tell you about the thermodynamics for the transfer of a nonpolar solute from an aqueous solution to a nonpolar solvent, and how might this relate to the hydrophobic interactions that are considered to play a significant role in driving protein folding?
The thermodynamic data shown in the table below provide insight into the n physicochemical basis of what are sometimes loosely referred to as "hydrophobic interactions". As you can see, the Gibbs free energy changes, where Delta G = Delta H -T Delta S, for the transfer of a hydrocarbon from an aqueous solution to a nonpolar solvent is negative in all cases, which is what you would expect. However, what is perhaps surprising is that these transfer processes are endothermic for aliphatic compounds and athermic (Delta H = 0) for aromatic compounds. That is, it is enthalpically more or equally favorable for nonpolar molecules to dissolve in water than in nonpolar media. In contrast, the entropic component of the free energy change, -T Delta S, is large and negative. What does this tell you about the thermodynamics for the transfer of a nonpolar solute from an aqueous solution to a nonpolar solvent, and how might this relate to the hydrophobic interactions that are considered to play a significant role in driving protein folding?
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Reid WolffLv2
3 Mar 2019
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