Include a hand drawn reaction mechanism for the reaction that was performed
for the synthesis of aspirin. A generalized mechanism will not be accepted. The mechanism should show the flow of electrons via arrow pushing in the correct direction.
DIRECTIONS Acetie anhydrite can cuuse severe dis very haomful ir Inhaled.nnd It renets a hoodi avoid contact with do n it nway from water Sulfurle ncid causes chemleat burns that cnn eyes. Wenr gloves and nvold contact. h the iuld,do not breathe its vnpurs, and bee iloroform is harmful ir ininled or usorted eeted human earcinogen. Avoid contact with the ii, d and it is a do not breathe its vapors. e Standard Scale Reaction. Under the hood, add 5.0 mL of ncetic anhydride to 15. of salicylic acid in a dry 125-m. Erlenmeyer lask. Add 3 4 drop centrated sulfuric acid. and stir or swirl [OP-10 the r OP-7 the mixture in a 45-50 C water bath with frequent swirling or netic stirring until the salicylic acid dissolves, and then for about 5 minutes more. Let the flask stand at room temperature until crystallization begins lt no product has precipitated when the solution is near room temperature resulting mixture. THeat induce crystallization by scratching the wall of the lask at the surface of the solution with a glass stirring rod, or by adding a few seed crystals of pure as- pirin. When a heavy precipitate has formed. stir in 30 mL of cold water and break up any lumps with a lat-bottomed stirring rod. Cool the mixture in an ice/water bath until crystallization is complete. Separation. Separate the aspirin from the reaction mixture by vacuum filtration [OP-16] and wash it on the filter [OP-26al with several portions of ice-cold water. using a small amount of the wash water for transfer. Save about 20 mg of the crude product in a clean, labeled test tube for analysis, and transfer the rest to a beaker Purification. Recrystallize [OP-28] the aspirin from an ethanol/water misx ture, using the following procedure to reduce the likelihood of hydrolysis st Dissolve the aspirin in the minimum volume of boiling 95% ethanol and add another 1 mL of ethanol, measuring the total volume of ethanol used Add twice that volume of warm (60 C) water to the solution while it is still at the boiling point, and swirl to mix.If any precipitate forms, heat the solu tion gently until it is clear, but do not boil it. Let it cool slowly to room tem perature, induce crystallization if necessary, and cool it in an ice/water bat until crystallization is complete. Collect the aspirin by vacuum filtratio OP-16], and wash it on the filter [OP-26a] with ice-cold water. Save anothe small sample of the aspirin in a clean, labeled test tube for analysis. D [OP-26b) and weigh the remaining aspirin. Analysis. Place about 20 mg of salicylic acid in a clean, labeled test tub then dissolve each reserved aspirin sample and the salicylic acid in 1 ml o 95% ethanol. The aspirin samples need not be completely dry. Add a drop
