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6 Nov 2019
B. You have a mixture of compounds I-III and want to isolate all three using chromatography. A TLC plate of the mixture run with 10% ethyl acetate in hexane yield shown at right. Assuming that you have already packed a silica column with hexane, desribe how you would go about running the flash column using hexane, 10% ethyl acetate in hexane, and 50% ethyl acetate in hexane. Clearly explain with what solvent you would expect each compound to elute and why, based both on the TLC results and the structure of each molecule flash column s the result C. A mixture of the two molecules shown at right is dissolved in water and then the solution is extracted with ethyl acetate. One of the molecules hasa Kpe value of 7.8, and the other has a Kpe value of 0.014. Identify which K,e value is associated with each molecule. Explain your choice both in terms of the definition of Kpe as well as by using chemical reasoning (structure and intermolecular forces) to discuss the interactions of each molecule with both of the solvents esradiol HO mannitol он он D. Your lab partner suspects that you have residual ethyl acetate in your crude caffeine sample. You have acquired the following data: product mass, melting point, IR spectrum, 'H NMR spectrum, CNMR spectrum, and mass spectrum. Discuss how each of the above would be affected by the presence of ethyl acetate in your sample. Be specific in your discussion of what effect, if any, you would expect in each. Show transcribed image text
B. You have a mixture of compounds I-III and want to isolate all three using chromatography. A TLC plate of the mixture run with 10% ethyl acetate in hexane yield shown at right. Assuming that you have already packed a silica column with hexane, desribe how you would go about running the flash column using hexane, 10% ethyl acetate in hexane, and 50% ethyl acetate in hexane. Clearly explain with what solvent you would expect each compound to elute and why, based both on the TLC results and the structure of each molecule flash column s the result C. A mixture of the two molecules shown at right is dissolved in water and then the solution is extracted with ethyl acetate. One of the molecules hasa Kpe value of 7.8, and the other has a Kpe value of 0.014. Identify which K,e value is associated with each molecule. Explain your choice both in terms of the definition of Kpe as well as by using chemical reasoning (structure and intermolecular forces) to discuss the interactions of each molecule with both of the solvents esradiol HO mannitol он он D. Your lab partner suspects that you have residual ethyl acetate in your crude caffeine sample. You have acquired the following data: product mass, melting point, IR spectrum, 'H NMR spectrum, CNMR spectrum, and mass spectrum. Discuss how each of the above would be affected by the presence of ethyl acetate in your sample. Be specific in your discussion of what effect, if any, you would expect in each.
Show transcribed image text Nestor RutherfordLv2
29 Jul 2019