Question

Okay I'm not sure I actually understand what this question isasking...

So according to Bronsted equation, we know that the hydrolysis ofester catalyzed by a general base is proportional to the basicstrength of the catalyst. But, in enzyme-catalyzed reactionsinvolving a general base as a catalyst the most critical factorthat determines the efficiency of the catalyst is not the strengthof the base but its effective concentration. Give explanation tosupport this above statement.

Okay I'm totally lost. I know what the Bronsted equation is and iknow what a general base is.

What is being asked here and how do I go about explaining it? Do Ihave to explain why and how the concentration plays a major roleand not the strenght of the base?! Please help.....