HSC 4555 Lecture Notes - Lecture 7: Retrovirus, Immunoglobulin D, Antigen

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17 May 2023
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Malignant neoplasm is cancer may not be survivable. Proto-oncogenes gain of function mutation (over activity of gene contributes) Normal genes that are responsible for coding proteins play a role in regulating cell growth and differentiation. Tumor suppressor genes loss of function mutation (too little activity) Allows cells to divide and increase in number. When express at high level, turns normal cell into tumor cell. Normally code for: growth factors, receptors, cytoplasmic signaling molecules, nuclear transcription factors. 4 ways of activation from proto-oncogene to oncogene. Proto-oncogene in the cell suffers a mutagenic event. Causing dna sequence maybe lost/ damaged proto-oncogene active abnormally. Error in chromosome replication cause extra copies of pro-oncogene. Defective p53 allows damaged unstable cells to proliferate. A single aberrant gene is unable to induce malignancy. Process by which cancer tumor grows new blood vessels in order to grow. Doesn"t develop until late stages of development.

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