HSC 4555 Lecture Notes - Lecture 15: Natural Killer Cell, Red Blood Cell, Bone Marrow
Document Summary
White blood cells ( leukocytes ) granular leukocytes: neutrophils, eosinophils, basophils agranular leukocytes, lymphocytes = t cells, b cells, and natural killer cells, monocytes. Childhood: axial skeleton & appendicular skeleton both. Adult: axial skeleton red marrow, appendicular skeleton. Hemoglobin is the oxygen-carrying protein in the mature red blood cell. Consists of two pairs of polypeptide chains, the globins. Each globulin contains heme molecule composed of iron and protoporphyrin molecule. Erythropoiesis is regulated by the concentration of hemoglobin in blood. In response to decreased hemoglobin the kidney secretes erythropoietin. Changes in oxygen and carbon dioxide during respiration. Globin portion broken down into amino acids & recycled. Heme portion split into iron (fe 3+ ) and biliverdin (green pigment) Each hemoglobin molecule can bind 4 atoms of oxygen. Average person has about 15 g of hemoglobin per 100 ml of blood. Partial pressure of oxygen reflects the pressure or tension that oxygen exerts when it is dissolved in blood.
