NTS 135 Lecture Notes - Myelin, Choline, Sphingomyelin

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8 Dec 2022
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Choline is important for proper development of the fetal brain. Milk and other dairy products supply some choline: functions of choline. Choline recognized as an essential nutrient in 1998. Functions in all cells: cell membrane structure, single-carbon metabolism, nerve function and brain development lipid transport, cell membrane structure. Precursor for several phospholipids: phosphatidylcholine (lecithin) accounts for about half of phospholipids in cell membranes, contributes to membrane flexibility, allows for presence of water/fat- soluble compounds, single-carbon metabolism. Acetylcholine: choline-containing neurotransmitter: associated with attention, learning, memory, muscle control, and other functions. Sphingomyelin: choline-containing phospholipid: part of myelin sheath that insulates nerve cells. Pregnancy: choline high in amniotic fluid important for developing fetal brain low choline level: poor brain development and decreased learning ability: lipid transport. Choline is a component of lipoproteins: choline deficiency leads to, decreased production of vldl inability of liver to export fats to body, results in fatty liver, scarring, common in cirrhosis, getting enough choline.

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