CH 111 Lecture Notes - Lecture 1: Fibrin, Fibrinogen, Collagen
Document Summary
Hemostasis prevents blood loss vessels are damaged } blood is leaving those vessels. Require clotting factors and substances released by platelets and other insured tissues. Three steps in this process vascular spasms induce vasoconstriction. Platelets attach to damaged vessels forms a plug platelets stick to collagen fibers that are exposed when a vessel becomes damaged platelets do not stick to vessel walls because collagen is not exposed. when activated. Series of reactions use clotting factors ( pro coagulation) mostly plasma pnotiens. Blood clotting phase: intrinsic : all molecules needed are present in the blood, extrinsic 8 depends on a pnotien that is not in the blood = tissue factors. Ae (lo) , ae u c calcium ions , phospholipid surface. Throws bonin stimulates the conversion of fibrinogen into fibrin that will form mesh structure. Disorders of hemostasis: thromboembolic disorders result from undesirable clot formation, bleeding disorders result in a deficiency of blood clotting hemophilia.
