MEDICAL PARASITOLOGY Chapter Notes - Chapter 65: Plasmodium Vivax, Plasmodium Falciparum, Plasmodium Malariae

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gmonotes

25 Apr 2022

School

University of the Philippines Manila

Department

Biology

Course

MEDICAL PARASITOLOGY

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Document Summary

Caused by apicomplexan parasites of the genus plasmodium. Generally occurs between 45 n and 40 s. Species: falciparum, vivax, malariae, ovale, knowlesi tropical areas worldwide both tropical and temperate zones east horn of africa, central asia and the. Indian subcontinent, southeast asia, and latin america occurs worldwide but to a much lesser extent than p. falciparum or p. vivax. occurs primarily in western africa and. Southeast asia only species to date not to have been introduced to the americas: malarial parasite of old world monkeys several regions of southeast asia potentially life-threatening but are difficult to distinguish from p. malariae microscopically. Naats detection of parasite-specific dna - provide sensitivity and specificity generally not appropriate or available for smaller laboratories not typically performed on a stat basis, as is necessary for detection of acute disease. Acquired via rupture of placental vessels with maternal-fetal transfusion. *neither transfusion-related or congenital malaria is expected to relapse because exoerythrocytic schizogony does not occur.

Related Questions

An area has two different Anopheles species, both of which can vector Plasmodium, although Plasmodiumdevelops best and is transmitted best by species B. Species A is dominant because its larvae outcompete species B in the main shared breeding sites, small lakes and ponds. Therefore the population of B is currently small. The small lakes and ponds are also the source for the main food source in the region, fish, grown in fish farms. There is grazing land, but other than chickens, the local population does not have livestock. Species A is largely endophagous and endophilic, species B is exophilic. In other sites, both species A and B will also feed on cattle, and B appears to prefer cattle. Both species also like to roost during the hot day in rock overhangs and small caves. To give some context to your answers use the IPM terminology considered in class.

A) The national malaria control agency sends in a new person to develop a malarial control strategy. (S)he recommends oiling the lakes and ponds, and intensive house spraying . Discuss why each of these two options would be a good or bad idea. In your answer consider effects on species A, species B, and malaria incidence. And remember, the idea is to help the local population.

B) Develop an alternative targeted strategy that might work well in this situation. Explain why this would be a good fit. Use only strategies that have been used successfully in the field, and avoid "just spray everything" strategies. Explain why your strategy should work.

After roughly 15 years we have the first malaria vaccine going into phase 4 trials. Meanwhile a Zika vaccine is starting phase 2b trials, only 2-3 years after the first major outbreak in Brazil.

A) Discuss in some detail why it is so much more difficult to develop a vaccine for malaria than for e.g. the Zika or rubella virus. I am looking for at least 2 reasons, and a brief explanation of those reasons. Just stating that one is complex and the other simple is insufficient. If that is what you want to say, back it up with facts.

B) Both the CRISPR bacterial defense system and the adaptive immune system in mammals have means to recognize âsignaturesâ of invading organisms. In what way are the two systems different?

The malaria control team in a given area has access to 5 different drugs, chloroquine, mefloquine, pyrimethamine, amodiaquine, and artimisinin. Nothing else will be available for the foreseeable future. Some resistance to all 5 is already observed.

A) Provide a strategy to maximize the time you can cure malaria using these 5 drugs. Explain why you want to use this strategy (what is the idea behind your plan), and be precise: when do you plan to use what drugs. What are the potential problems you can face and how do you plan to deal with them? Remember, you are working with humans, not robots.

B) Hypnozoites are forms of P. vivax and P. ovale that are dormant, with barely any metabolic activity. After long periods of time (months, a year), they can be re-activated start invading red blood cells, and causing malaria. Explain why artemisinin would or would not be a good drug for people suspected of carrying hyponozoites.

This is for Biology of disease vectors.

What are the five important consequences with respect to pathogens/parasites living within a host (possibly including a vector?) Can you provide a brief description of what is meant by each?

The five consequences of vector interactions is

1. genome erosion (lose genome content),

2. metabolic streamlining

3. adaptation to different hosts,

4. molecular mimicry,

5. interdependent metabolism.

As just one example, what is remarkable about the genome of Theileria annulata? By the way,who might the genus name of this organism be named after? is T. anulata a vector-borne organism? If so, what is the vector?

Why might you expect the metabolic network of plasmodium to be less extensive than that of anopheles? Which of the two is able to make the most amino acids from scratch

Why do we need something like network theory to eventually understand what is going on in a vector infected networks to be redundant? What might be the eventual goal of applying such network algorithms to vector-pathogen relationships?

Question 1 Which characteristic(s) of mitochondria andchloroplasts supports their existence as independent prokaryoticcells that were engulfed by eukaryotic cells?

Question 1 options: their size presence of their own DNA theirself-replication by binary fission all of these characteristicssupport that mitochondria and chloroplasts were independentprokaryotic cells that were engulfed by eukaryotic cells

Question 2 Mitochondria originated from __________, which wereengulfed during __________ endosymbiosis. Chloroplasts originatedfrom __________, which were engulfed during __________endosymbiosis.

Question 2 options: aerobic bacterium; primary; cyanobacteria;primary anaerobic bacterium; primary; cyanobacteria; secondarycyanobacteria; primary; aerobic bacterium; secondary cyanobacteria;primary; aerobic bacterium; primary

Question 3 Saved Secondary endosymbiosis refers to the processby which

Question 3 options: prokaryotes acquired chloroplasts.prokaryotes acquired mitochondria. eukaryotic cells engulfedcyanobacteria. eukaryotic cells with mitochondria engulfed aphotosynthetic.

Question 4 Saved Though there are exceptions, __________ is acommon reproductive strategy among protists.

Question 4 options: sexual reproduction by mitosis asexualreproduction by mitosis binary fission asexual reproduction bymeiosis

Question 5 Protists with chloroplasts are __________ that maketheir own food. Protists that lack chloroplasts ___________ and arethus heterotrophic; this group is generally known as__________.

Question 5 options: parasites; ingest food; protozoansheterotrophs; photosynthesize; plankton photosynthetic autotrophs;ingest or absorb food; protozoans green algae; are parasites;plankton

Question 6 An endosymbiotic protist that does not cause diseaseis likely

Question 6 options: plankton. a protozoan. a parasiticheterotroph. a photosynthetic autotroph.

Question 7 The euglenoids are

Question 7 options: euglenoids can be all of these things.photosynthetic organisms with chloroplasts. heterotrophic organismswithout chloroplasts. flagellated freshwater unicellularorganisms.

Question 8 African sleeping sickness and Chagas disease arecaused by

Question 8 options: amoeboids found in zooplankton. euglenoidswith chloroplasts. photosynthetic protists. parasiticflagellates.

Question 9 Amoeboids feed by

Question 9 options: photosynthesis, by which they make their ownfood in their chloroplasts. phagocytosis, which occurs aspseudopods surround and engulf prey. decomposing dead organisms.absorbing nutrients from their surroundings.

Question 10 Foraminiferans and radiolarians

Question 10 options: share a clade with the amoeboids. areamoeboids with shells called tests. have pseudopods, but are notamoeboids. do not have pseudopods, though they do have shells,called tests.

Question 11 A ciliate might have __________, which dischargestructures that are useful in defense or prey capture.

Question 11 options: anal pores trypanosomes contractilevacuoles trichocysts

Question 12 Ciliates reproduce __________ and have __________ tocontrol metabolism and reproduction.

Question 12 options: both sexually and asexually; two types ofnuclei sexually; a single nucleus asexually; two types of nuclei bybinary fission; a nucleoid

Question 13 The nonmotile apicomplexan Plasmodium vivaxcauses

Question 13 options: Chagas disease. vaginitis. African sleepingsickness. malaria.

Question 14 Which phase of Plasmodium vivaxâs life cycle takesplace in the human liver? In the mosquito carrier?

Question 14 options: the sexual phase; the asexual phase theasexual phase; the sexual phase

Question 15 __________ molds are found in forests, fields, andin soil. They exist in two forms, individual amoeboid __________and diploid multinucleated __________.

Question 15 options: Slime; sporangium; flagellated cells Water;sporangium; flagellated cells Slime; cellular slime molds;plasmodial slime molds Water; cellular water molds; plasmodialwater molds

Question 16 __________ are among the most numerous of allunicellular algae in the oceans and produce a major portion of theearths oxygen supply.

Question 16 options: Red algae Sporozoa DinoflagellatesDiatoms

Question 17 The phenomenon known as red tide is caused by

Question 17 options: population explosions in dinoflagellates.population explosions in red algae. built up remains of diatoms.bacterial invasion of the phytoplankton.

Question 18 The seaweed observed on the shoreline in the northtemperate zone, sometimes called kelp, is

Question 18 options: green algae. blue-green algae. red algae.brown algae.

Question 19 Ice cream, sherbet, and cream cheese are made fromalginate, a pectinlike material produced by __________ algae. Anemulsifying agent used in cosmetics and chocolate, as well as thewrappings for sushi rolls are made from extracts or parts of__________ algae.

Question 19 options: brown; green brown; red red; green green;brown

Question 20 Saved Green algae are believed to be closely relatedto the first plants, and are classified as plants by someauthorities, because both groups

Question 20 options: have a cell wall containing cellulose.possess chlorophylls a and b. All of these choices accuratelycomplete this statement. store reserve food in the form ofstarch.

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MEDICAL PARASITOLOGY Chapter Notes - Chapter 65: Plasmodium Vivax, Plasmodium Falciparum, Plasmodium Malariae

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