PHARMACOLOGY Lecture Notes - Lecture 2: Smoking Cessation, Diazepam, Dosage Form

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Absorption is the movement of a drug from its site of administration into the central compartment and the extent to which this occurs. Bioavailability - used to indicate the fractional extent to which a dose of drug reaches its site of action from the site of administration. Happens when a fraction of the administered and absorbed dose of drug will be inactivated or diverted in the intestine and liver before it can reach the general/systemic circulation and be distributed to its sites of action. If the metabolic or excretory capacity of the liver and the intestine for the drug is large, bioavailability will be reduced substantially rst-pass e ect. It is also useful to bypass the hepatic rst pass metabolism. This method avoids the mixing of the drug with food and other gastric juices which may impede absorption. Enteral administration: passes through the gut or gastrointestinal tract; safest, most common, convenient and economical method.

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