BIOL 4305 Chapter Notes - Chapter 7B: Site-Specific Recombination, Immunoglobulin Light Chain, Light Heavyweight
24 Sep 2021
Department
Course
Professor
Document Summary
Quiz 21lb) : dna rearrangements difference between general homologous recombination and site - specific recombination . General homologous recombination occurs at region of extensive sequence homology. Site specific recombination occurs between specific. Dna sequences ; usually only small region of homology . site - specific recombination. Mediated by proteins that recognize specific dna target regions " programmed " Not primarily mediated by complementary base pairing. Invertebrates , good example of this is production of. Dna rearrangements antibodies b t - cell receptors. Encoded by unique lymphocyte genes going through site - specific recombination of gene segments structure of an immunoglobulin. Vcvariable ) region : encodes n-terminus of ly. Ji joining ) region : encodes another part of polypeptide variable region: ( constant ) region : encodes carboxy terminus of 16. Site-specific recombination between a v3 a j. A pro motor in front of that v is brought close to enhancer between the j"s and c"s region.
