L07 Chem 481 Lecture 14: Lecture 14
5 Mar 2017
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*oh hydroxyl free radicals are the most reactive species. The *q + o2 reaction has a low probability of occurrence (0. 4%-4%) In hypoxia, the q* accumulates in the body and then o2 is reintroduced, so can easily cause o2* to form. (stroke) H2o2 + 2gsh -> h2o + gssg (uses selenium, antioxidant) *o2 -> aconitase (or proteins in general) -> fe2+ released. Fe2+ + h2o2 -> fe3+ + *oh + -oh. Activate nadph oxidase when bacterium is engulfed to produce *o2- which will kill the bacterium. Chronic granulomatous disease: don"t have nadph-oxidase = lack primary defense mechanism. Vitalism: doctrine that living organisms are fundamentally different from non- living entities because they contain some non-physical element or are governed by different principles than are inanimate things. Inorganic phosphate added to yeast extract stimulated and prolonged fermentation. All 10 reactions of glycolysis discovered by 1940. Inhibitors to increase pools of intermediates for structural characterization.
