L41 BIOL 4810 Lecture Notes - Lecture 15: Arginine, List Of Sequence Alignment Software, Cell Nucleus
12 May 2020
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Sanger sequencing: one of the earliest ways to sequence a small amount of dna (1-2 kb, still used today during molecule biology. 4: i. e. confirming a cloned gene is correct, while used for smaller genomes like viruses and bacteria, whole genome sequencing or next-generation sequencing is used today for genome sequencing. Next-gen sequencing: much better for sequencing very large genomes, multiple techniques for this but all rely on sequencing many small rads (~20-50 nt) then reconstructing the entire genome computationally, won"t be converged in this course. Darwin"s evolutionary tree: this is the only figure in on origin of species, darwin used it to illustrate the interrelationships of all living things, shows how more recently diverged species are the most similar to each other. Using sequence data to piece together evolutionary history: sequence differences in dna or proteins can be used to construct evolutionary trees, the sequences retain a record of evolutionary history, evolution recycles gene into new functions.
