BIOL 340 Lecture Notes - Lecture 4: P16, Dna Replication Factor Cdt1, P21
Document Summary
Cell cycle or cell-division cycle part 2 https://www. youtube. com/watch?v=eqjqha8hsj0 https://www. youtube. com/watch?v=wrh7xg7q6sg https://www. youtube. com/watch?v=vljf8pf8spw. Role of cyclin dependent kinase (cdks) several subheadings. Cell-cycle control system: the cell-cycle control system is a cyclically operating biochemical device constructed from a set of interacting proteins that induce and coordinate the essential processes involved in duplication and division of cell"s contents. Major cell cycle regulatory proteins details in next sections. Protein kinases and protein phosphatases that modify cdks. Three family members (cdc 25a, b, c) in mammals; Cdc 25c is activator of cdk 1 at the onset of mitosis. Sic 1 (budding yeast) p 27 (mammals) p 21 (mammals) p 16 (mammals) Helps cells to withdraw from cell cycle when they terminally differentiate; Phosphorylation by cdk 2 triggers its ubiquitination by scf. Suppresses g1/s-cdk and s-cdk activities following dna damage in g1; Catalyzes ubiquitination of regulatory proteins involved in g1 control, including ckis (sic 1 in budding yeast; p 27 in mammals);
