BIOL 118 Lecture Notes - Lecture 24: Type Three Secretion System, Macrophage, Apoptosis

• School: University of San Diego
• Department: Biology Courses
• Course: BIOL 118
• Professor: Terry Bird

Document Summary

Evolved fr common simpler ancestor (w/ flagellum) Yp can grow & burst out of macrophage. Yp can get in by binding on protein receptor ccr5* To avoid it change shape of protein to avoid it. Hiv uses ccr5 as a receptor to get into protein. Causes aids bc destroys cells that fight infection. *however there are ppl strongly resistant to hiv. Most ppl in n europe have resistance mutation. Hypothesis: mutation designed to fight another bacteria* Mutation spread outward fr n euro (gradually) Ability for capsule & injectisome, infection of immune system cells, survival inside macrophage. Soil bacterium that can infect ground rodents. Can cause mild upset stomach; not deadly pathogen for rodents. Bc infects hind gut of flea, plugging digestive tract & killing it. Acquired mutations that allowed it to colonize upp rather than lower digestive tract inactivating stomach bowl regurgitating bacteria*** Innovation that allowed bacteria become deadly pathogen using a flea as a vector for host to host.