BIOL 522 Lecture Notes - Lecture 2: Linkage Disequilibrium, Brian Charlesworth, Background Selection
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> restriction enzymes recognise seq where they have to chop dna, look at diff sequences to see cut or not cut, can see seq variation and sort by size. > look at using southern blot (acrylamide gel -> radiograph with fragment sizes) Background selection describes the loss of genetic diversity at a non-deleterious locus due to negative selection against linked deleterious alleles. It is one form of linked selection , where the maintenance or removal of an allele from a population is dependent upon the alleles in its linkage group. Deleterious mutations will result in less variation in the population. Constantly getting rid of deleterious variation (and get rid of more stuff in lower recombination rate regions), pattern will repeat, ongoing process of purifying selection (brian charlesworth) Linkage = single molecule with lots of genetic variation on it that is stuck together. Linkage disequilibrium = non random combination of alleles stuck together on one molecule , mechanism for background selection.
