PSYCH 220 Lecture Notes - Lecture 8: Mania, Major Depressive Episode, Bipolar I Disorder
Document Summary
Progressive disorder of the nervous system that impairs movement. Neuropsych disorders: begins with mild tremor, progresses to stiff/uncontrolled movement. Symptoms caused by reduced dopamine in substantia nigra: exact cause of neural degradation is unknown. Treatment with levodopa: compound converted to dopamine in the brain. Made significant progress in disease and pathology by studying animal models. Can use hydroxydopamine lesions (6-ohda) to deplete da. Classi(cid:272) (cid:373)oto(cid:396) defi(cid:272)its do(cid:374)"t usuall(cid:455) appea(cid:396) u(cid:374)til late(cid:396) i(cid:374) p(cid:396)og(cid:396)essio(cid:374) New work with animals shows we may be able to predict pd with early changes in vocalizations. Mptp (cid:373)odel of pa(cid:396)ki(cid:374)so(cid:374)"s: discovered when a group of young druggies appeared at a hospital with. Pa(cid:396)ki(cid:374)so(cid:374)"s s(cid:455)(cid:373)pto(cid:373)s: resulted from a type of synthetic heroin mptp. Can be given to animal models to recreate many of the symptoms. Rats are resistant, and different kinds of mice strains vary in response: has been helpful for de(cid:448)elopi(cid:374)g t(cid:396)eat(cid:373)e(cid:374)ts, (cid:271)ut (cid:272)a(cid:374)"t tell us a(cid:271)out (cid:272)ausatio(cid:374)
