BIOLOGY 207 Lecture Notes - Lecture 17: Dactinomycin, Transcription Bubble, Stem-Loop
Document Summary
Requires a gc-rich region of rna, as well as 4 8 consecutive uridine residues. Antibiotics are made to target cellular machinery that is not shared with eukaryotes: antibiotics must meet 2 fundamental criteria, kill or retard the growth of a pathogen, not harm the host, rifamycin b. Non-selectively intercalates between gc base pairs in dna. Can have harmful side effects on our cells as well. Inhibits transcription elongation it"s not just used for bacterial infections, it"s actually used to treat cancers that replicate rapidly. Some are 15 seconds, others can be 30 minutes. Stabilities of the different kinds of rnas differ drastically. trna and rrnas are much more stable. (are needed to make proteins: have modified bases that are less susceptible to rnase digestion. Concept check : the termination of transcription can be caused by which of the following: stem-loop structure, rho factor, stop codon, a and b, a, b, and c.
