ANSC 452 Lecture Notes - Lecture 4: George Weah, G1 Phase, E2F
15 Nov 2020
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Document Summary
Transformation from epithelial cellsto mesenchymal alls (emt) leads to many processes such as embryogenesis, organ development, limb development, & tissues. Ent contributes to accumulation of extracelular motrix in chronic fibrotic disorders. Emt requires a change in cell adhesion. Intro cellular domains act as reversible scaffold for signaling. G1 is the most variable phase y so we need to have some kind or regulation. Go checkpoint + between g7&s phase; internal cues (size) orexternal cenvironment. Cyelins & cyclin depend ano kinases phosphorylate to induce progression cyclin activity boolds& degrades with pears at mitosis in g1 cycle is started by cyelino. Lo mapk signaling results in coros, coron, & myc, which expresses cyclino destrean cylling binds to cor 4/6 listargets pro cell cycle inhibitor. Ls binds to & inhibits e2f, but cannot bind it phosphorylated by cyclin d/cal. 4 e2f is important fors-phase genes & transcription factor for cycline poor. Transcription factors that call for cyclin oc my c; c-jun; c-tos)
