ANSC 452 Lecture Notes - Lecture 5: P21, Oncogene, Retinoblastoma Protein
15 Nov 2020
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Document Summary
Once apopto some is formed cospace 3 8 7 act downstream. Bcl-2 family stabilizes & protects 89 8inst damage and + apoptosis. Bax/bad are pro- apoptotic proteins (cid:10) growth factor signaling can mediaze pro zant apoptotic factors. Ap proteins bind to prevent actrity of caspases can a cylin o p27 binds to (inhibits cell cycle) geline. Benign & may be caused by abnormal growth is does not growth uncontro mably, to spread. Oncogenes mutation i loss of function ; typically dominant. Oncogenes gain of function (brick on the gast only one must be mutated. Tunnor supressor gencs hold growth in check y loss of function cut the brakes) s cell cycle inhibitors/apoptotic inhibits. Myc oncogene; transcription factor for cyclins decreases p21. 4 stimulated by writ, shh, & egf to sasid tumor in lymph nodes leatra nodol sites. P53 tumor supressor gepe; stops damaged ona from completing the cell cycle. Lo can signal for apoptosis et in cancer.
