CBIO 3400 Lecture Notes - Lecture 4: Digestion, Lysosome, Glycosylation
2 Mar 2019
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Document Summary
Learning objectives: explain the structure and function of the er, golgi and lysosomes, describe the dynamic nature of these organelles. *rough er is also involved in membrane synthesis: protein, synthesis, folding, glycosylation, vesicular transport, gatekeeper role. Smooth er functions: lipid synthesis, phospholipids, cholesterol, drug detoxification, calcium homeostasis. Golgi structure and function: comprised of cisternae and vesicles, located near the nucleus, juxtanuclear , positioned by microtubules. Sides of the golgi: cis face, receives vesicles from er, returns vesicles to er, trans face, buds vesicles for transport to other locations. Functions of the golgi: protein sorting in the secretory pathway, carbohydrate synthesis, glycosylation, phospholipid synthesis. Lysosome structure and function: acidic organelle (ph 5, size and shape varies greatly, functions, digest extracellular materials, degrade old organelles, lysosomes are one of the organelles in the secretory pathway, lysosome-resident proteins are made at the er.
