ADSC 4300 Lecture Notes - Lecture 17: Insulin-Like Growth Factor 1, Adipose Tissue, Autocrine Signalling

• School: University of Georgia
• Department: Animal and Dairy Sciences
• Course: ADSC 4300
• Professor: Liu

Document Summary

Growth hormone is a protein hormone: direct actions: mediated through gh receptors, since growth hormones are protein hormones, proteins can enter the cell freely. The receptor is a membrane: growth hormones have such a broad effect on the body, major effects of growth hormones, direct actions, reduced glucose transport & metabolism. Increase insulin-like growth factor-i (igf-1) production: indirect actions- modulated through release of other hormones or growth factors, most indirect actions on growth are mediated through igf-1 and igf- It"s through many hormone growth factors, but there is one: igf binding proteins bind igf to make it become a most important one igf-1 complex. Increase half-life of igfs in circulation: carry igf to target cells, modulates binding of igf with igf binding proteins with tissues, there are 6 binding proteins, these proteins can inhibit or promote. Igf actions can be autocrine, paracrine (neighboring cells), and endocrine (enter the bloodstream).