ADSC 4300 Lecture Notes - Lecture 8: Endoplasmic Reticulum, Muscle Contraction, Muscle Fatigue

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Muscle injury: loss of muscle function (strength) caused by the physical disruption of muscle structures involved in producing and/or transmitting force: muscle fatigue is a temporary loss of muscle strength, while muscle injury can require. This force causes damage to important contractile proteins such as myosin, actin, etc: physical disruptions: sarcolemma can tear. If you have less calcium uptake, you have less muscle strength. Contraction of muscle: brain sends signal to spinal (cid:272)ord that will send , action potential comes down the nerve. Transverse tubules allow action potentials to travel to muscle fibers. In the transverse tubules, you have voltage sensors that are sensitive to voltage changes in the membranes: sr have calcium release channels that interacts with voltage sensors. Injury & degradation: large holes in muscle fibers; edema (swelling of the muscle) Inflammatory phase: very important to muscle recovery.

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