HUN 4446 Lecture Notes - Lecture 18: Sepsis, Peripheral Neuropathy, Hypoglycemia

• School: University of Florida
• Department: Food Science and Human Nutrition
• Course: HUN 4446
• Professor: Anne Mathews

Document Summary

Increased ast/alt ratio: ratio = > 1. 0, > 2. 0 = strongly suggestive of. Increases: caused by kidney"s not getting enough blood flow, na retention, ascities, accumulation of fluid in peritoneal cavity, contributors, portain htn secondary to fibrosis, reduced oncotic pressure of plasma due to failure of liver to synthesize albumin. Increased retention of na: splenomegaly, hyperammonemia, related to continued alcohol abuse, malnutrition often concurrent. Intestinal maldigestion/malabsorption: alcohol causes inflammation of stomach, pancreas, Increased catabolism: cho/glucose, decreased glucose uptake, decreased glycogen synthesis, decreased gluconeogenesis (hypogly, usually in late phases, hypoglycemia, zn, mg, k. Increased urinary losses: k = nausea, vomiting, zn affects absorption/transport of vitamin a and vice versa, vitamin a, malabsorption, decreased hepatic stage, direct effect on retinol metabolism. Impaired conversion to retinoic acid: vitamin d, malabsorption, cholestasis, pancreatic insufficiency. Interference with metabolism: cannot be activated if liver and kidney are not functioning, hydroxylation in liver and kidney. Inhibits absorption: soap formation, fat is malabsorbed, less vitamin d.