NTDT451 Lecture 28: case study # 28
9 Jun 2017
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Explain the rationale and current recommendations regarding glutamine, arginine and omega-3 fatty acids for this patient population. Nutrients particularly important to enhance wound healing in trauma patients include ascorbic acid, zinc, selenium, copper and partly alpha-tocopherol. Currently, it is not recommended that parenteral glutamine supplementation be used routinely (**excessively) in the critical care setting. Trials have been conducted and found higher mortality rates in patients who received glutamine compared to those who received a placebo, antioxidants, a combination of en/pn glutamine and/or a combination of glutamine with antioxidants. It is rationalized that the combination of amino acid imbalance (caused by glutamine supplementation) and severity of the patient"s illness/trauma accounts for increased mortality rates in trials and meta-analyses. Nonetheless, glutamine is recognized as an important nutrient for wound healing due to its provision of energy and dna bases in rapidly proliferating cells.
