BIPN 105 Lecture Notes - Lecture 3: Nernst Equation, Cell Membrane, Resting Potential

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1 Apr 2019

School

UCSD

Department

Bioinformatics

Course

BIPN 105

Professor

Catalina Reyes Gonzalez

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Resting membrane potential (vm, voltage: sodium-potassium pump creates and maintains a concentration gradient, atp used to pump sodium out and potassium in, creates small electric gradient. Rest of electric gradient created by role of k: pump moves k+ inside the cell, creating higher concentration of k+ in icf, so there"s a concentration gradient. This causes a diffusion force: cell membrane relatively permeable to k+, not na+. When there"s an equilibrium of push-pull, no movement (chemical force = electrical force), which occurs at resting membrane potential: need both driving force and pathway to diffuse out, nernst equation: predicts the equilibrium potential (eion) [ion] = concentration of ion: eion = voltage due to the ion, equilibrium potential allows us to predict membrane resting potential based on concentrations of a particular ion. Ek+ = -90. 1 mv: role of na+ in resting membrane potential, higher concentration of na+ on outside causes na+ to diffuse in.

Related Questions

6. Consider the presence of hemoglobin in the catheter bag. Whatsymptom would this loss of

hemoglobin most strongly and immediately be linked to in thepatient?

A. Loss of blood volume

B. Loss of heartbeat

C. Drop in blood oxygen saturation

D. Liver failure

When a neuron is stimulated, the area of the membrane at thepoint of stimulation becomes

more permeable to Na+. If a cell starts at resting potential(-70mv), and is then stimulated:

A. The membrane voltage will become < -70mV, because Na+will move OUT of the cell.

B. The membrane voltage will become > -70mV, because Na+will move OUT of the cell.

C. The membrane voltage will become < -70mV because Na+will move INTO the cell.

D. The membrane voltage will become > -70mV because Na+will move INTO the cell.

. At the peak of the action potential, the Na+ voltage-gatedchannels close, and K+ voltage-gated

channels open in response to the positive membrane potential.In order to return the cell to its

negative resting potential quickly:

A. K+ will diffuse along its concentration gradient INTO thecell.

B. K+ will diffuse along its concentration gradient OUT of thecell.

C. Na+ will reverse its direction of diffusion OUT of thecell.

D. The sodium-potassium pump will move Na+ OUT of the cell andK+ INTO the cell.

E. None of the above would return the cell to its negativeresting potential quickly.

You experiment with higher concentrations of toxin and findcases when the cell could not

repolarize at all or, if it began to repolarize, itimmediately depolarized again. This tells you that

the toxin:

A. Prevents voltage-gated K+ channels from opening.

B. Increases the speed that the Na+ ion channels open.

C. Prevents the Na+ ion channels from closing.

D. Makes the Na+ ion channels close too soon.

E. Doesn

lavenderclam549

1. The plasma membrane of liver cells contains a glucose uniportthat transports glucose by facilitated diffusion. When the[glucose] is higher inside the liver cell than the [glucose]outside the liver cell, the glucose uniport will

A. couple the transport of glucose out of the cell to thehydrolysis of ATP

B. couple the transport of glucose into the cell to thehydrolysis of ATP

C. switch to a closed conformation, allowing no transport ofglucose

D. transport glucose out of the cell by passive transport

E. transport glucose in of the cell by passive transport

2. Unlike the positive charged ion shown in the middle diagramof figure 11-4B, K+ is higher in concentration inside the cell. Howwill the membrane potential of a cell at rest (shown in both themiddle and right-hand diagrams of Figure 11-4B) affect theelectrochemical gradient for K+?

A. The membrane potential will increase the electrochemicalgradient

B. The membrane potential will decrease the electrochemicalgradient

C. The membrane potential will have no effect on theelectrochemical gradient

3. Which of the following proteins carries out activetransport?

A. gluclose symport

B. Bacteriorhodopsin

C. ABC transporter

D. NA K pump

E. All of the above

4. Aquaporin will not transport Na+ ions because

A. Two asparagine residues in the channel prevent the passage ofNa+ ions by binding the oxygen of each water molecule as it passesby

B. Na+ ions are repelled by the positive charges at the entranceto the channel

C. Na+ ions cannot make contact with the carbonyl (C=O) groupson all four sides of the channel

D. The passage of Na+ ions is energetically unfavorable becauseone side of the channel is hydrophobic in nature

5. The acetylcholine receptor is different from other channelproteins we have discussed, such as the K+ leak channel,because

A. The acetylcholine channel is composed of a single polypeptiderather than multiple subunits

B. The acetylcholine channel transports Na+ ions against theconcentration gradient for sodium

C. The acetylcholine channel has a much smaller diameter thanother channel proteins

D. The acetylcholine channel transports ions with theirassociated shell of water molecules

E. The acetylcholine channel is always open, and never switchesto a closed conformation

6. After opening briefly along the axon of a neuron,voltage-gated ion channels switch to an inactivated conformationthat slowly returns to the original closed conformation of theprotein. This slow change in conformation, requiring about amillisecond, is important because

A. all of the ions that were transported across the membranewhen the ion channels were open must be actively transported backto the other side of the membrane, restoring the originalconcentration gradient, before the ion channels can open again

B. ATP hydrolysis is necessary to drive this energeticallyunfavorable change in conformation

C. it prevents the action potential from reversing direction andtraveling back toward the cell body of the neuron

D. the channel protein must be dephosphorylated in order tocomplete the transport process and return to the originalnonphosphorylated conformation

limeelephant476

Which of the following statements is TRUE regarding sea anemones?

	None of the answer options is correct.
	Spongesânot sea anemonesâpossess what is considered to be the âsimplestâ nervous system found in animals.
	Because sea anemones are âsimpleâ organisms, these animals only possess motor neurons; sensory neurons or interneurons are never found in sea anemones.
	Although sea anemones possess ânet-likeâ nervous systems, these animals have brains located at their bases (near where they would attach to rocks).
	Although sea anemones lack definitive brains, they do possess ganglia that serve a similar function to the paired ganglia of flatworms.

Some people have low levels of calcium circulating in the blood, a condition known as hypocalcemia. While for many this disorder has little to no effect, for some it can be life-threatening. How could low levels of calcium harm an individual?

	Low levels of calcium would not have any effect on synaptic transmission.
	Low levels of calcium would cause sustained depolarization of the presynaptic cell.
	Low levels of calcium would result in fewer signals sent between the pre- and postsynaptic cell.

Cephalization is: the

	All of these choices are correct.
	development of a brain within the head of an animal.
	concentration of sensory organs within the head end of an animal.
	development of a âhead endâ in an organism.

Which of the following are TRUE about the resting membrane potential? (Select all that apply.)

	It results from voltage-gated sodium channels remaining open for long periods of time.
	It results from K⁺ ions diffusing out of the cell.
	It results from the sodium-potassium pump moving more Na⁺ ions out of the cell than K⁺ ions into the cell.

Afferent and efferent neurons differ in:

	their size.
	the directionality of the information they send.
	their pattern of myelination.

A neuron that responds to the environment is a(n):

	interneuron.
	homeostatic neuron.
	motor neuron.
	sensory neuron.

Which of the following is NOT the role of an interneuron?

	stimulating a muscle to contract
	conveying information from the internal environment of an animal
	relaying information from sensory to motor neurons
	maintaining homeostasis

Where are postsynaptic cell receptor proteins synthesized?

	the Golgi apparatus
	the lysosome
	the cytoplasm
	the rough endoplasmic reticulum

Inhibition of the flexor muscle during the knee-extension reflex is an example of:

	homeostasis.
	reciprocal inhibition.
	negative feedback.
	All of these choices are correct.

10.

What type of cells produce myelin for sensory neurons?

	pyramidal neurons
	glial cells
	melanocytes
	astrocytes

BIPN 105 Lecture Notes - Lecture 3: Nernst Equation, Cell Membrane, Resting Potential

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