BIPN 102 Lecture Notes - Lecture 9: Reversal Potential, Conformational Change, Cyclic Adenosine Monophosphate
3 Jun 2017
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Document Summary
The nt in the nmj is called ach which binds to receptors in the postsynaptic membrane called ach receptors. Ach then gets broken down by an enzyme and gets transported back into the postsynaptic cleft. Some nt"s get transported in pieces and other get transported back whole: nt"s can also diffuse out of the synapse. When we"re thinking about termination neurotransmission we think about the prolonging the action of the nt at the synapse. Drugs that prolong the action of nt in the synapse include: stimulants like amphetamines that keep dopamine there, ecstasy, cocaine-inhibitor of dopamine transporter, ssri- selective serotonin which is a reuptake inhibitor for depression and anxiety. Adenylyl cyclase which is an enzyme that drives the promotion of atp to camp. We have now gone from one single ligand to 3 molecules of atp which activate 3 molecules of protein kinase a and finally there is a response: two types of g-protein, gs-stimulates, gi- inhibits.
