BIPN 100 Lecture 27: BIPN 100 Lecture 27

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chocolatebeetle359

13 Jun 2018

School

UCSD

Department

Biology/Animal Physiol & Neurosc

Course

BIPN 100

Professor

Dr. Kimberley Cooper

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BIPN 100 Lecture 27

6/8/2018

• Interstitial fluid of the renal cortex is 300 mOsm

• As you go further and further into the medulla, the osmotic gradient increases, from 300

mOsm to 1200 mOsm

• NKCC: sodium-potassium-chloride channel in the ascending loop of Henle

o In the thick segment solutes are reabsorbed, but water cannot follow because

thee’s o auapois

▪ One potassium in, one potassium in, and two chlorides in from the lumen

of the loop of Henle

▪ There are leak channels for K and Cl on the basal side, and the sodium

ATP pump moves the Na out

▪ So then when the filtrate enters the distal tubule, it is hyposmotic

• Similar characteristics in the epithelium of the distal tubule and collecting duct: effected

by hormonal control for water or solute reabsorption

• Vasopressin (aka ADH) has an effect on the distal nephron

o When we need to conserve water, the hypothalamus will produce ADH and is

stored in the PPG. Hypothalamus tells the PPG to release ADH into the

bloodstream, and when it gets to the collecting duct, it binds to vasopressin-2

(V2) receptors. A membrane receptor (cannot cross bilayer) and activates a GS

transduction pathway which activates AC to produce more cAMP, causing an

increase in protein kinase A (PKA), which phosphorylates. It phosphorylates the

storage vesicles where the AQ2 are stored in. The aquaporin is then inserted and

water can be reabsorbed into the interstitial fluid into the peritubular capillaries

• Three stimuli control vasopressin

o High osmolarity causes vasopressin release

▪ There are osmoreceptors in the hypothalamus. If osmolarity goes up

higher than 280 mOsm, the hypothalamus signals PPG to release

vasopressin

o Low BP

o Low blood volume

▪ Generally goes hand in hand with low BP

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• Countercurrent exchange

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Related Questions

1. Which of the following vessels, if stimulated to vasoconstrict, would cause increased filtration in the glomerular capillaries?

(a) Afferent arterioleâ(c) Efferent arteriole

(b) Vasa rectaâ(d) Peritubular capillaries

2. Which of the following CORRECTLY describes the flow of filtrate through the renal tubule?

(a) Glomerulus Ã Distal convoluted tubule Ã Ascending limb of nephron loop Ã Descending limb of nephron loop Ã Proximal convoluted tubule Ã Collecting duct

(b) Glomerulus Ã Proximal convoluted tubule Ã Descending limb of nephron loop Ã Ascending limb of nephron loop Ã Distal convoluted tubule Ã Collecting duct

(c) Glomerulus Ã Proximal convoluted tubule Ã Ascending limb of nephron loop Ã Descending limb of nephron loop Ã Distal convoluted tubule Ã Collecting duct

(d) Glomerulus Ã Distal convoluted tubule Ã Descending limb of nephron loop Ã Ascending limb of nephron loop Ã Proximal convoluted tubule Ã Collecting duct

3. Tubular ______________ occurs when certain substances (i.e. ions, drugs) are removed from the bloodstream and placed back into the renal tubule.

(a) Eliminationâ(c) Secretion

(b) Reabsorptionâ(d) Filtration

4. Which of the following is TRUE about the reabsorption process in the proximal convoluted tubule?

(a) Na + ions are actively transported out of the tubule and into the peritubular capillaries

(b) Negatively charged ions (e.g. chloride) are transported out of the tubule in response to the movement of sodium

(d) All of the above

5. Which of the following statements is FALSE about the glomerulus and the processes that occur there?

(a) Capsular hydrostatic pressure refers to the pressure of fluid pressing on the capsule and opposes filtration

(b) Net filtration pressure in the glomerulus is the difference between forces favoring filtration and forces opposing filtration

(d) Vasoconstriction of the efferent arteriole lowers glomerular filtration rate

6. The descending limb of the nephron loop is impermeable to water while the ascending limb of the nephron is permeable to water.

(a) Trueâ(b) False

7. Which of the following vessels takes blood out of the renal corpuscle and returns it to the bloodstream?

(a) Peritubular capillary systemâ(c) Vasa recta

(b) Efferent arterioleâ(d) Afferent arteriole

8. Under the influence of ADH, the ___________________ and the _________________ become permeable to water and water is reabsorbed.

(a) Proximal convoluted tubule, Nephron loop

(b) Distal convoluted tubule, Nephron loop

(d) Distal convoluted tubule, Collecting duct

9. What is the name of the region inside the bladder bounded by the two uretal openings and the urethra?

(a) Trigoneâ(c) Mucous layer

(b) Detrusor muscleâ(d) Transitional epithelium

10. During the accumulation of urine, the bladder distends, allowing stretch receptors in the transitional epithelium to be stimulated.

(a) Trueâ(b) False

lemongoat70

1) A drop of urine would follow this path

a) renal pyramid/major calyx/minor calyx/renal pelvis/ureter

b) minor calyx/major calyx/renal pyramid/renal pelvis/ureter

c) renal pelvis/minor calyx/major calyx/renal pyramid/ureter

d) renal pyramid/minor calyx/major calyx/renal pelvis/ureter

2) The production of filtrate starts at

a) Loop of Henle

b) capsular space

c) distal convoluted tubule

d) proximal convoluted tubule

3) Major reabsorption of water happens by ____at the _____

a) contransport, distal convoluted tubules

b) Cl- shift, nephron loop

c) countercurrent, nephron loop

d) countercurrent, ureter

4) Angiotensin II causes production of ____to increase Na + reabsorption in the _________

a) renin; collecting duct

b) aldosterone; PCT

c) ADH; nephron loop

d) aldosterone; collecting duct

5) Most of the reabsorbed compounds from the filtrate end up in the

a) peritubular capillary

b) urine

c) nephron loop

d) DCT

6) Reabsorption of urea happens by

a) transcellular movement

b) by paracellular movement

c) by cotransport with glucose

d) by HCO3- movement

7) Transport Maximum, in urinary system terms, refers to

a) proteins performing âtransportâ out of the filtrate at maximum rate

b) the reason why a diabetic produces large volumes of diluted urine

c) excess filtrate components being urinated out of the body

d) All choices are correct

8) Urine does not drop below pH 4.5 because

a) proteins that move H+ into filtrate stop working when too much H+ builds up in filtrate

b) proteins in urine neutralize acid

c) H+ are always buffered

d) the buffering system in urine does not run out

9) Hyperkalemia will

a) activate adrenal cells to secrete aldosterone

b) can stop the heart

c) No choices are correct

d) cause reduced excitability of neurons

e) All choices are correct

amaranthgnu452

1) A drop of urine would follow this path

a) renal pyramid/major calyx/minor calyx/renal pelvis/ureter

b) minor calyx/major calyx/renal pyramid/renal pelvis/ureter

c) renal pelvis/minor calyx/major calyx/renal pyramid/ureter

d) renal pyramid/minor calyx/major calyx/renal pelvis/ureter

2) The production of filtrate starts at

a) Loop of Henle

b) capsular space

c) distal convoluted tubule

d) proximal convoluted tubule

3) Major reabsorption of water happens by ____at the _____

a) contransport, distal convoluted tubules

b) Cl- shift, nephron loop

c) countercurrent, nephron loop

d) countercurrent, ureter

4) Angiotensin II causes production of ____to increase Na + reabsorption in the _________

a) renin; collecting duct

b) aldosterone; PCT

c) ADH; nephron loop

d) aldosterone; collecting duct

5) Most of the reabsorbed compounds from the filtrate end up in the

a) peritubular capillary

b) urine

c) nephron loop

d) DCT

6) Reabsorption of urea happens by

a) transcellular movement

b) by paracellular movement

c) by cotransport with glucose

d) by HCO3- movement

7) Transport Maximum, in urinary system terms, refers to

a) proteins performing âtransportâ out of the filtrate at maximum rate

b) the reason why a diabetic produces large volumes of diluted urine

c) excess filtrate components being urinated out of the body

d) All choices are correct

8) Urine does not drop below pH 4.5 because

a) proteins that move H+ into filtrate stop working when too much H+ builds up in filtrate

b) proteins in urine neutralize acid

c) H+ are always buffered

d) the buffering system in urine does not run out

9) Hyperkalemia will

a) activate adrenal cells to secrete aldosterone

b) can stop the heart

c) No choices are correct

d) cause reduced excitability of neurons

e) All choices are correct

10)In your body, chloride (Cl-) can be found in its highest concentration in

a) extracellular fluid

b) intracellular fluid

c) Neither choice is correct

11) Diuretic abuse leads to

a) All choices are correct

b) two choices are correct

c) No choice is correct

d) dehydration

e) athletes being accused of doping

f) hypotonic hydration

12) Long diffusion distance, low blood pressure, and impaired circulation are the result of

a) hypernatremia

b) edema

c) hyperkalemia

d) water toxicity

13) In males FSH is under feedback control by _____ and is down regulated when _________reaches high concentrations

a) inhibin, testosterone/sperm #s

b) testosterone, inhibin/sustentocyte #s

c) ADH, inhibin/sustentocyte #s

d) LH, testosterone/sperm #s

14) Testosterone production is done by ____-cells

a) posterior pituitary

b ) interstitial endocrine

c) anterior pituitary

d) sustentocytes

15) Upon _____of estrogen/progesterone, the ____phase of the uterine cycle begins

a) increase; menstrual

b) decrease; menstrual

c) increase; proliferative

d) decrease; secretory

16) Progesterone

a) All choices are correct

b) is low in the luteal phase

c) No choices are correct

d) raises in the follicular phase

e) is high along with estrogen during the follicular phase

17) Which nephron is most responsible for urine concentration?

a) cortical nephrons

b) Juxtamedullary nephrons

c) Neither

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BIPN 100 Lecture 27: BIPN 100 Lecture 27

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