BIPN 100 Lecture Notes - Lecture 5: Myelin, Cardiac Muscle, Saltatory Conduction

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13 Jun 2018

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BIPN 100 Lecture 5

4/11/2018

• Action potential

o VGNaC activate in response to depolarization suprathreshold

▪ Na is moved into the cell by both its electrical and chemical gradients

▪ When the channels open, the permeability increases

o VGNaC inactivate when the cell reached ~+30mV

▪ The sodium channels have two gates: an activation gate and an

inactivation gate

▪ The inactivation closes not in response to any voltage difference, but just

after a few milliseconds have passed

▪ For the channels to reset, repolarization has to occur

▪ at rest, activation gate is closed and inactivation gate is open

▪ the activation gate opens and the inactivation gate is opened once the

cell is activated

▪ the atiatio gate is still ope ad the iatiatio gate is losed, it’s

inactivated

▪ deactivated is once the channel goes back to having the activation gate

closing and the inactivation gate opening

o eause of the iatiatio gate that loses, the ell does’t depolaize all the

ay to sodiu’s euiliiu at ~+60V

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