PNB 2265 Lecture Notes - Lecture 20: Submucous Plexus, Muscularis Mucosae, Lamina Propria

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Parietal peritoneum: lines walls of abdominal cavity. Visceral peritoneum: covers the surface of organs. Histology of gi tract (conserved structure throughout gi - with modifications) Outside, has mesentery, aka adventitia, structure, protection, outermost. Myenteric plexus - major site of innervation in gi tract. Support of small vessels and lymph nodes. For absorption secretion mucous production. Contraction with smooth muscle immediately behind bolus. Small intestine = weak (more time for absorption) Small and large intestine (no net forward movement. What will each of the following do to smooth muscle contractility in the gi tract: opening a calcium channel. Increase contraction in production of camp: increased mlckinase activity. Increase contraction, atp hydrolysis and cross bridge: increasing mlcphosphatase activity. Decrease contraction, atp hydrolysis and cross bridge: an agonist for a gpcr using gi . Increase contraction, inhibitor gi camp increase kinase a: stimulating a gpcr that uses gs . Decrease contraction, stimulator: inhibiting beta-2 adrenergic receptor.

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