MCB 2210 Lecture Notes - Lecture 21: Chromatin, Dna Microarray, Chronic Myelogenous Leukemia
3 Apr 2016
School
Department
Course
Professor
Document Summary
Cancer causes roughly one-fifth of the deaths in the us each year. Carcinomas are cancers that arise from epithelial cells and are the most common cancers in humans. Leukemias and lymphomas arise from blood cells. Several fundamental cellular properties are altered during carcinogenesis (the generation of cancer): cancer cells break the most basic rules of cell behavior that build and maintain organisms. Numerous proteins have been identified because abnormalities in their function can lead to uncontrolled cell growth, increased cell division, decreased cell death, enhanced cell migration, etc. These proteins are involved in dna repair, cell signaling, cell cycle control, cell growth, programmed cell death, cytoskeletal rearrangements, and tissue architecture. Cancer cells are defined by two heritable properties: (1) they reproduce in defiance of the normal restraints on cell growth and division, (2) they invade and colonize territories normally reserved for other cells.
