SOC GEN 5 Lecture Notes - Lecture 3: Girolamo Fracastoro, Germ Theory Of Disease, Miracle Drug
25 Apr 2020
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Aims: basic biology: antibiotics and bacteria history of antibiotics in war and medicine examine mindset of miracle drug keywords: germ theory koch"s postulates selecting toxicity antibiotics penicillin germ theory of disease: predecessors. Humorism (~500) bc miasma theory (~1600-1870s) bad air from decomposed water infections not passed by individual but by air, water, poor hygiene. "some material which being accidentally swallowed might attach itself to the mucous membrane of the small intestines and there multiply itself by appropriation of surrounding founding events of epidemiology discovery of animalcules robert koch, 1843- 1910 founder of microbiology. Rst to link a speci c microorganism with a speci c disease discovery vibrio causes cholera. Koch"s postulates method: isolate and reinoculate assumption: bacteria are pathogenic intervention: vaccination and hygiene emphasis: prevention. 1935: prontosil isoniazid (1952) still used to treat tuberculosis the discovery of pcn in 1928 by sir alexander eming the di erence it made.
