PCB 3233 Lecture Notes - Lecture 1: Fragment Antigen-Binding, Cytidine Deaminase, Complementarity-Determining Region

66 views5 pages
12 Apr 2016
School
Course
Professor

Document Summary

5) bonds; also contain various amounts of carbohydrate atachments have diferent lengths and sugar atachment in structure, no hinge region in igm or ige but have four. Heavy chain isotypes to form igg, iga, igm, ige, igd - have difering efector funcions. Igg - four subclasses; most abundant ig in blood, fc fragments bind to fc receptors on pathogens; crosses placenta to provide humoral immunity to developing and newborn infant. Igm - pentameric with j-chain in blood, otherwise it is a b cell receptor; irst anibody produced by b cells; early response eiciency due to avidity. Igd - low quaniies in circulaion and present on b cell as a receptor with igm; not much known. Hv also = cdr (complementarity determining region) there are three cdrs in each domain. Cdr 3 has the highest diversity: soma ic hypermutaion is a type of speciic point mutaion. Involves acivaion-induced cyidine deaminase (aid), which converts cyidine to uracil.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents

Related Questions