PCB 3233 Lecture Notes - Lecture 3: Adaptive Immune System, Degranulation, Mhc Class I
Document Summary
Possess high levels of surface mhc class ii molecules. Process and present peptide antigens to t cells. Their role is to recognize microbial antigens through innate receptors & process & present them to t cells of the adaptive immune system. Hold intact antigens in specialized areas of lymphoid tissues. Found in germinal centers of secondary lymphoid tissues. Found in skin, connective tissue and mucosal epithelial tissue of respiratory and digestive. Precursors differentiate in the bone marrow and mature in tissues. When activated, they degranulate, they release pharmacological mediators (histamine) which cause. Attract leukocytes to the site of degranulation. In bone marrow cells responsible for blood platelet production when its in cytoplasm its fragmented. Bind to immune complexes composed of antigen and antibody carry complexes to liver where these are cleared by kupffer cells. Kupffer cells = phagocytic cells of liver that line hepatic sinusoids. Method of communication amongst cells to send out warning for in ammatory response to activate.
