NUR 3145 Lecture Notes - Lecture 4: Reuptake Inhibitor, Trimipramine, Central Nervous System
Document Summary
Neurotransmitters: acetylcholine (excitatory or inhibitory, learning, memory, muscle movement, myasthenia gravis, alzheimer"s (loss), parkinson"s (increase, serotonin (inhibitory) & norepinephrine (excitatory) Involved in mood, depression, pain regulation: antidepressants, cns stimulants, dopamine (excitatory) Sedative-hypnotic drugs: anxiolytic, hypnotic - produce sleep, sedative - produce calm & relaxation, reduces excitement (valium) (ativan) (xanax, niravam) (versed) (halcion) (restoril) (klonipin) (librium) Benzodiazepine receptor agonists: class iv, potentiate gaba, end in am (-olam, -epam, diazepam lorazepam, alprazolam, midazolam triazolam, oxazepam, estazolam temazepam flurazepam, clonazepam, chlordiazepoxide, chlorazepate. Iv use profound hypotension, respiratory & cardiac arrest: gastric lavage/charcoal, saline, dialysis flumazenil (romazicon) reduces sedation only, oral take with food for gi upset. Iv diazepam, lorazepam: very hazardous, avoid intra-arterial injection & extravasation inject into tubing as close to vein as possible. Melatonin agonist ramelteon (rozerem: not a controlled substance, activates melatonin receptors, for chronic insomnia, for difficulty with onset of sleep, not sleep maintenance, rapid onset (30 minutes, very well tolerated somnolence, dizziness, fatigue.
