PUBHLTH 101 Lecture Notes - Lecture 6: Analysis Of Variance, Twin, Heredity
15 Oct 2016
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Document Summary
Genetics science of heredity; involves study of cells, individuals, their offspring, and the populations from which they derive. Epidemiology deals with incidence, distribution, and control of disease in a population. Genetic epidemiology the genetic causes of diseases in populations: the role of genetic factors and their interactions with environmental factors in the etiology of disease. To disentangle and quantify contributions: genes, shared environment. Adoption design: siblings are genetically related, but grow up in unrelated environments, and vice-versa. Classic twin design: identical (mz) and non-identical (dz) twins grow up in same environment. Gxe interaction genotypes differ in their sensitivity to environmental influences. Ge correlation non-random placement of genotypes within environments: a ge correlation can occur from offspring: Actively seeking environments which are a function of genotype. Passively inheriting genetic and environmental influence from parents. Monozygotic (identical) twins are derived by the division of a single fertilized ovum (zygote: mz twins share all genes in common.
