BMB 240 Lecture Notes - Lecture 8: Oxidoreductase, Catabolism, Microorganism

• School: University of Maine
• Department: Micro and Molecular Biology
• Course: BMB 240
• Professor: Catherine Hopper

Document Summary

Stored in energy-rich compounds light high-energy phosphate compounds . Nicotinamide adenine dinucleotide (nad), nad phosphate (nadp), flavin adenine dinucleoide (fad). If carbon intermediaes from degradation of organic compounds- hetertotrophy; from carbon dioxide or inorganic compounds autotrophy. Protein catalyst: substant the increases the reate of a reaction without being permanently altered. Control rate and extent: recruit reactants to active site. Speeds up reaction up to 1,000 times faser by lowering ea. Constitutive enzyme continuously present, always producing this enzyme. Each enzyme has specific ph and temperature optima- correlating with optimum conditios for microbial growth. Denaturing of enzyme death to microbe. Competitive inhibitor: directly competes with binding of substrate to active site. Example, inhibition of folic acid synthesis by sulfa drugs. Non-competitive inhibitor: binds enzyme at site other than the active site; changes enzymes conformation so that is becomes less active (heavy metals denature protein) Has a positive or negative effect on enzyme activity.