BSCI 105 Lecture Notes - Lecture 5: Kinetochore, Metaphase, Spindle Checkpoint

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Cell division: growth and regulation of the cell cycle. Production of new cells from existing cells. One cell grows and divides into two daughter cells. Reasons for cell division: growth, repair, maintenance/renewal. Chromosomal replication: linked to cell division, anchors to membrane. Opposite poles (centrioles: copies are pulled apart. Eukaryotes: cytokinesis division of cytoplasm. Physical division of cell membrane and contents. Cytoskeleton rearranges itself a band of actin gathers around it, and is surrounded by myosin to bend and pull the actin closer together to get smaller: mitosis division of chromosomes into daughter cells. Chromatid single copy of a chromosome and dna. Sister chromatids only occurs during mitosis joined together chromatids. Equal cell division - two genetically identical daughter cells of the same type. Unequal cell division daughter cells of different types. Interphase: g1 (g0) 1 chromatid, s dna synthesis, g2 2 sister chromatids. Prophase: chromosomes condense, nucleoli disappear, centrioles (asters) separate, mitotic spindle forms. Prometaphase: nuclear envelope dissolves, kinetochores form.

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