MIC 401LEC Lecture Notes - Lecture 15: Major Trauma, Monocyte, Immunoglobulin D
18 Aug 2020
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Document Summary
Mechanism cause autoimmunity: failure of self-tolerance (central tolerance and peripheral tolerance, genetic. Infections: molecular mimicry (microbial ags sometimes cross-react with self-ags), can cause cardiac damage. Females more severely a ected by autoimmune disease (over 90%) Hormonal in uences: castrated male more susceptible to autoimmunity, androgen treatment of female reduces, female develop more vigorous th1 responses, estrogen may stimulate. Most treatments are not cures (reduce symptoms) Primary: defective antibody response and cell mediated immunity, hereditary complement defects, defects in phagocyte function and leukocyte adhesion, genetic a ect lymphoid or myeloid lineages (may be single gene or complex), a ect organ development. Defective antibody response: increased susceptibility to pyogenic infections (defect in b cell function or failure in t cell signals. Igg: toxic neutralization (binds active site or cause structure change), agglutination, bacteriolysis. Igm: rst ig to appear in immune response and produced by the neonate, pathogenesis, toxic neutralization, opsonization, agglutination, bacteriolysis, major antigen on b cell.
