MIC 401LEC Lecture Notes - Lecture 13: Innate Immune System, Thymus, Antigen Presentation
18 Aug 2020
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Document Summary
Phagocytes circulate throughout the body, looking for potential threats, like bacteria and viruses, to engulf and destroy. Macrophages are e cient phagocytic cells that can leave the circulatory system by moving across the walls of capillary vessels. They release cytokines in order to signal other cells to an area with pathogens. Secretes highly toxic proteins and free radicals which cause tissue damage during allergic reaction. Located in thymus, lower gastrointestinal tract, ovaries, uterus, spleen, and lymph nodes. Serve as bridge between the innate immune system and the adaptive immune system. Mast cells are important for wound healing and defense against pathogen via in ammatory response. Histamine cause blood vessel to dilate (increase blood ow and cell tra cking to the area of infection). Neutrophils are phagocytic cells as granulocytes (contains granules in cytoplasm) very toxic to bacteria and fungi, stop them proliferating or die on contact. Release histamine making basophils and mast cell key players in allergic response.
