BSC 444 Lecture Notes - Lecture 13: Igor Tamm, Reoviridae, Viral Nonstructural Protein

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 444
• Professor: Duffy

Document Summary

Rotavirus virion structure: triple-layered icosahedral capsid with spoke-like structures (rota = wheel in latin), 60- 85 nm in diameter: genome is segmented dsrna. Rotavirus capsid structure: each of the 3 layers is constructed from a distinct viral protein (vp, inner layer = vp2 (t = 1, middle layer = vp6, outer layer = vp7 (t = 13) Inner and middle layers are perforated: middle layer contains the spokes , outer layer is glycosylated, glycoproteins not usually found in naked viruses, vp7 is associated with a membrane within the cell before it is incorporated into the virion. Rotavirus genome: eleven dsrna segments (rna 1-11, each rna segment encodes one protein (except rna 11 which encodes 2 proteins in. Infection of single cell with different strains leads to reassortment viruses different reading frames: twelve proteins encoded by rotavirus genome, 6 structural proteins (vp, 6 non-structural proteins (nsp)