BSC 431 Lecture Notes - Lecture 30: Exhalation, Monocyte, Aerosolization
22 Mar 2016
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Document Summary
Mold form in nature and in the lab growing at 25-30 c, slow growth. Yeast form when in tissue or grown on enriched media at 37 c. Cause disease in both healthy and immunocompromised individuals. Disease usually initiated by inhalation of spores from a specific environment (cid:1) (cid:1) Can disseminate throughout the body from the lungs. Also known as endemic" pathogens in that their natural habitat is delimited to specific geographic regions (cid:1) (cid:1) (cid:1) (cid:1) Yeast form is distinctive compared to the mold form. Cells are spherical, transparent, multinucleated and have thick. Found on decaying organic matter in nature and is inhaled from soil and leaf litter (cid:1) No person-to-person transmission but laboratory-acquired blastomycosis has been reported (cid:1) (cid:1) (cid:1) (cid:1) Dogs are more susceptible than humans (10x more) Inhalation of infectious particles (conidia-reproductive structure containing spores) (cid:1) (cid:1) Infiltration of macrophages and neutrophils and granuloma formation.
