BSC 310 Lecture Notes - Lecture 31: Glutamine Synthetase, Operon, Glutamine
Document Summary
All of what we have discussed to date utilizes regulatory proteins to interact with dna (cid:1) Rna is also capable of regulating gene expression, both at transcription and translation (cid:1) Most common way for regulatory rnas to work is by base pairing with other rna molecules (cid:1) Need regions of complementary sequence but can prevent translation of mrnas as double-stranded rna cannot be translated (cid:1) Antisense rna- small rnas with complementary sequences to the coding sense of their mrna. Transcription of anti-sense rna is enhanced when the gene needs to be turned off (cid:1) Trans-srnas are encoded in intergenic regions so are spatially separated from their mrna targets; this usually limits their complementarity to their targets so use a small protein (hfq) to facilitate their interaction (cid:1) Hfq and similar protein are called rna chaperones as they help small. Rna molecules to maintain their correct structure (cid:1) (cid:1) (cid:1) Riboswitch- rna molecule that resembles a repressor or activator.