MBBB 301 Lecture Notes - Lecture 4: National Center For Biotechnology Information, Similarity Measure, Before Present

• School: Towson University
• Department: Molecular Biology, Biochemistry and Bioinformatics
• Course: MBBB 301
• Professor: All

Document Summary

2 most essential human genome browsers are ensembl and ucsc. Genome browsers display images (ideographs) of chromosome (genomic dna is organized in chromosomes) Protein sequence databases- almost all protein sequence info is from nucleic acid sequence translations and this missed a lot of details on the protein. Gene db looks for specific gene, nucleotide database looks for fragments of genes. Can find coding regions in sequence in genomic dna sequence by taking protein and graphing against its protein. Similar vs homology- homology is evolutionary relationship that exists or does not. Paralog- similar genes in same species. ortholog- different species from same ancestor. Pairwise sequence alignment- decides if 2 proteins (or genes) are similar or evolutionary conserved. If 2 proteins similar, then structures is too. Can identify motifs (small sections of dna. conserved) and domains (function of protein. conserved) that are shared between proteins. Basis of blast tool (compares sequence to all sequences in ncbi to see if similar)