BIOL 221 Lecture Notes - Lecture 1: Von Willebrand Disease, Thrombomodulin, Prostacyclin
10 Feb 2020
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Document Summary
Two other naturally occurring chemicals that limit coagulation are prostacyclin and thrombomodulin. Prostacyclin, secreted by endothelial cells lining blood vessels, inhibits platelet aggregation. Clinically, heparin can be used to decrease production of thrombin, thereby acting directly on the common pathway of coagulation. Aspirin can be used prophylactically in small doses to decrease clotting because it inhibits platelet aggregation. Coumadin) inhibits the action of vitamin k in the synthesis of certain procoagulants by the liver. Genetic bleeding disorders: hemophilia, recessive, x-linked genetic (more common) or autosomal diseases, affects procoagulants, von willebrand disease, common autosomal dominant bleeding disorder, von willebrand factor, affects platelets. Hemophilias (http://www. nlm. nih. gov/medlineplus/hemophilia. html) are genetic bleeding disorders in which inadequate amounts of functional procoagulants are produced. Hemophilias can be recessive, x-linked disorders or autosomal disorders. The most common type of hemophilia involves factor viii (hemophilia. Other less common types involve factor ix (hemophilia b) and factor xi (hemophilia c). Von willebranddisease is the most common genetic disorder of clotting.
