BIOL 221 Lecture Notes - Lecture 1: Helminths, Neutrophilia, Neutropenia
10 Feb 2020
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Granulocytes: neutrophils: polymorphonuclear neutrophils (pmns, highly mobile, phagocytic, think spot: what organelle would be abundant, lysozyme, neutrophilia, neutropenia. Neutrophils, also called polymorphonuclear neutrophils or pmns, are highly mobile phagocytic cells. (what organelle would you expect to be very abundant in these cells?) They are often the first responders to acute bacterial infections. Lysozymes secreted by neutrophils are responsible for the destruction of some types of bacteria. Neutrophilia occurs as a result of acute bacterial infection. Granulocytes: eosinophils: cytotoxic enzymes, target parasites (especially worms, lessen severity of allergic reactions, phagocytizing antibody-covered particles, secrete chemicals that break down inflammatory chemicals, eosinophilia. Eosinophils release cytotoxic enzymes to target parasites, especially worms. The also phagocytize antibody-covered particles (antigen-antibody complexes). Eosinophilia is associated with allergic reactions and parasitic worm infections. Granulocytes: basophils: release histamine (inflammation) and heparin (anticoagulant) Basophils are the least common type of leukocyte. Because they release histamine (an inflammatory agent) and heparin (an anticoagulant) when stimulated, they are associated with inflammation.
