VTPP 423 Lecture Notes - Lecture 25: Protamine Sulfate, Hypoaldosteronism, Fondaparinux
16 May 2020
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Heparin thrombin transforms fibrinogen into fibrin aka factorti. Clotformation targe g interact w antithrombin binds antithrombin ii inactivates thrombin factors9a ioa had 12a u irreversibly inactivates thrombin du ia u monitor ptt measures function of intrinsic pathway of coag cascade. T yz life doesn"t require monitoring eliminated renally. Heparin is safe in pregnancy doesn"t cross placenta. Fondaparinux than lmwh also only ia smaller binds antithrombin ii w1 higher specificity these 3. Factors 2 7 9 10 don"t work properly gamma carbox works on protein synthesis. Delayed anticoag effect noo 12 hr carboxylates protein cds canticoas. Factor 7 is 1st to te oral admin long 42 life narrow therapeutic window inr monitor pt extrinsic path n main comp 7. Usually l 2 3forthrombosis occurs acid residue glutamic prevention skin necrosis so coadmin wi heparin for 1st. Intracerebral hemorrhage reverse w reverse w uit k delayed. Ffp immediate few days augment warfarin substrate of cyp450 t cyp480 will warfarin effects.
