01:160:311 Lecture Notes - Lecture 3: Ethyl Acetate, Seed Crystal, Kidney Stone Disease
16 Nov 2018
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Document Summary
Concepts involved in recrystallization and how they are employed. Solubility: a solution with dissolved solute in hot solvent. Saturation level: solution becomes saturated with respect to the solute, which then recrystallizes. Nucleation- initiation of recrystallization; which can be a seed crystal, a speck of dust, or a scratch on the wall of the test tube. Saturation level goes up with low urine volume and high concentration of stone promoters. Nucleation on calcium phosphate - presents solid surface on which seed crystals form and. Choosing solvent and solvent pairs eventually grows. Ideal characteristics for solvent with respect to solute. Dissolves the solute completely when solvent is hot (at boiling point of solvent. Precipitates solute completely when solvent is cold. Realistic characteristics for solvent with respect to solute. Both solvents have to be miscible in each other. One solvent has to be a poorer solvent for solute than that of the other.
